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with an IC50 of <3 nM for DNA-PK
9H2/t8-/m0/s1
7-dimethoxy-2-(3
14(3):22-30
CHMFL-ABL-053 21061 with an IC50 of <3CHMFL ABL 053 (compound 18a) is a BCR ABL inhibitor with ABL1: IC50 of 70 nM. CHMFL ABL 053 is derived from a dihydropyrimidopyrimidine core scaffold based compound 27 (GNF 7). CHMFL ABL 053 inhibited the proliferation of CML cell lines K562 (GI50 = 14 nM), KU812 (GI50 = 25 nM) and MEG 01 (GI50 = 16 nM), through significant suppression of the BCR ABL auto phosphorylation (EC50 = 100 nM) and downstream mediators such as STAT5, Crkl and ERK's
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