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GNE-140 (5 mg/kg) has high bioavailability in mice
These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters
5 nM (PKC-ε)
Streptococcus pneumoniae
DT2216 60031 GNE-140 (5 mg/kg) has highDT2216 is a potent and selective degrader of BCL XL based on PROTAC technology. DT2216 inhibits various BCL XL dependent leukemia and cancer cells but considerably less toxic to platelets. Product information CAS Number: 2365172 42 3 Molecular Weight: 1542. 36 Formula: C77H96ClF3N10O10S4 Chemical Name: (2S,4R) 1 ((S) 2 (7 (4 ((R) 3 ((4 (N (4 (4 ((4' chloro 4,4 dimethyl 3,4,5,6 tetrahydro [1,1' biphenyl] 2 yl)methyl)piperazin 1 yl)benzoyl)sulfamoyl) 2
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