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R406 bound to the ATP binding pocket of Syk and inhibited its kinase activity as an ATP-competitive inhibitor (K(i) = 30 nM)
PubMed PMID: 30755068
org/wiki/TRV130)
ISRIB (trans-isomer)
O-Desmethyl gefitinib D8 Size:Contact [email protected] for quotation R406 bound to the ATPO Desmethyl gefitinib D8 is a deuterium labeled O Desmethyl gefitinib. O Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O desmethyl gefitinib is dependent on CYP2D6 activity. O desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays. Product information Molecular Weight: 440. 93 Formula: C21H22ClFN4O3 Chemical Name: 4 [(3 chloro 4 fluorophenyl)amino] 6 {3 [(2, 2, 3, 3, 5, 5, 6, 6
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