Cryptotanshinone Size:Solid 2 mg 4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4

4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4

dBET6 features highly increased cellular potency with evident degradation in the sub-nanomolar range

CCN1C2=CC=C(CNCC3=CC=CC=C3OC)C=C2C2=CC=CC=C12

CC-115 inhibits PC-3 cells proliferation with an IC50 of 138 nM

Cryptotanshinone Size:Solid 2 mg 4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4Cryptotanshinone is isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. The compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2 independent mechanism. Cryptotanshinone selectively inhibits STAT3 activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. It has been