PD-166793 2265 InChi: InChI=1S/C23H24FN5O/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18/h3-13

Name: PD-166793 2265 InChi: InChI=1S/C23H24FN5O/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18/h3-13
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SKU: 69960108400
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SKU: 69960108400

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Description

InChi: InChI=1S/C23H24FN5O/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18/h3-13

955365-80-7

1'-pyrano[3

Akiyama T E

PD-166793 2265 InChi: InChI=1S/C23H24FN5O/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18/h3-13PD 166793 is a potent, selective, orally active and widebroad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP 2, MMP 3 and MMP 13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP 1, 7 and 9 (IC50=6. 0, 7. 2, and 7. 9 M, respectively). PD 166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Product information CAS Number: 199850 67 4 Molecular Weight: 412. 30

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