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Chemical Name: MK-8776 S-isomer
Inhibition of MMPs and ADAM/ADAMTS
or 300 mg/kg twice per week in subcutaneous xenografts of KARPAS-422 and Pfeiffer cells
Wandinger-Ness A
MK-0752 Catalog No.:M7921-2 Chemical Name: MK-8776 S-isomerMK0752 is a synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell fate determination, cell survival, and cell proliferation. Product information CAS Number: 471905 41 6 Molecular Weight: 442. 90 Formula:
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