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H2O/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22
Smiles: O[C@H](CO)[C@@H](O)[C@H](O)[C@H](O)CO
InChiKey: ABSXPNGWJFAPRT-UHFFFAOYSA-N
Smiles: O=C(NCCS(=O)(=O)C1=CC=C(C=N1)C(F)(F)F)C1C=CC(Cl)=CC=1
PRT062607 Hydrochloride hydrofolate H2O/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22PRT062607, also known as P505 15, PRT2607, PRT62607, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti SYK activity that is at least 80 fold greater than its affinity for other kinases. P505 15 successfully inhibited SYK mediated B cell receptor signaling and decreased cell viability in NHL and CLL. Product information CAS Number: 1370261 97 4 Molecular Weight: 429. 91