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10(11): 2043-51
Deoxypodophyllotoxin evokes increase of intracellular Ca2+ concentrations in DRG neurons
InChi: InChI=1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6
6) partial agonist (IA = 50% and 67%
PF-04856264 892al-Glu(OSu)-OH 10(11): 2043-51PF 04856264 is a potent and selective Nav1. 7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1. 7, respectively. PF 04856264 has low potency against the rat Nav1. 7 channel. PF 04856264 shows analgesic effect. Product information CAS Number: 1235397 05 3 Molecular Weight: 437. 49 Formula: C20H15N5O3S2 Chemical Name: 3 cyano 4 [2 (1 methyl 1H pyrazol 5 yl)phenoxy] N (1,3 thiazol 2 yl)benzene 1 sulfonamide