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) results in a number of adverse effects
Chemical Name: 4-{5-chloro-2-[(propan-2-yl)amino]pyridin-4-yl}-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H
CAS Number: 1158838-45-9
L189 Size:Contact [email protected] for quotation ) results in a numberL189 is a novel human DNA ligase inhibitor, inhibits hLigI III IV with IC50 of 5 9 5 M. IC50 value: 5 9 5 M (for hLigI III IV)Target: DNA ligasein vitro: L189 is a competitive inhibitor with respect to nicked DNA. L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non homologous end joinging. L189 markedly increases killing of HCT116 colon cancer
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