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Rock-Klotz J
Formula: C19H16N6O4S
Recent Pat Cardiovasc Drug Discov
Formula: C27H26ClN3O7S2
YM 254890 Size:2mg solid Rock-Klotz JG protein inhibitor. Potently inhibits Gq 11 heterotrimeric G protein signaling. Inhibits ATP UTP induced Ca2+ increase in HCAE cells expressing P2Y2 receptor (IC50 = 50 nM); carbachol induced production of IP1 in CHO cells expressing M1 receptor (IC50 = 95 nM); and ADP induced Ca2+ increase in platelets, in vitro (IC50 = 2 M). Also inhibits Gs induced cAMP elevation and G protein coupled MAPK ERK signaling. Product information CAS Number: 568580 02 9
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