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(2012) ACS Chem Biol
InChi: InChI=1S/C12H30N2
Mercaptopurine
InChi: InChI=1S/C27H44N4O5/c1-4-6-8-12-24(34)30-22(18-20-13-15-21(32)16-14-20)26(35)31-25(19(3)5-2)27(36)29-17-10-7-9-11-23(28)33/h13-16
GSK2334470 - CAS# 1227911-45-6 C-202 free base (2012) ACS Chem BiolGSK2334470 is a potent 3 phosphoinositide dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM), which does not suppress the activity of 93 other protein kinases including 13 AGC kinases most related to PDK1 at 500 fold higher concentrations. GSK2334470 also inhibited T loop phosphorylation and activation of Akt. GSK2334470 will be a useful tool for delineating the roles of PDK1 in biological processes. Product information CAS Number: 1227911 45 6