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43 with total brain levels ~9× above the mGlu7 positive allosteric modulator (PAM) in vitro EC50
Br-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs
caspase 3/7 activity is also greater in ZZW-115 hydrochloride-treated cells
(-)-Huperzine A can ameliorate the learning and memory deficiency in animal models and AD patients
DSR-6434 )(human) TFA 43 with total brain levelsDSR 6434 is a potent and selective Toll like receptor 7 (TLR7) agonist, with EC50s of 7. 2 nM and 4. 6 nM for human and mice TLR7, respectively. DSR 6434 has a strong antitumor effect. Product information CAS Number: 1059070 10 8 Molecular Weight: 400. 48 Formula: C19H28N8O2 Chemical Name: 6 amino 2 (butylamino) 9 ({6 [2 (dimethylamino)ethoxy]pyridin 3 yl}methyl) 8,9 dihydro 7H purin 8 one Smiles: CN(C)CCOC1C=CC(CN2C(=O)NC3=C(N)N=C(NCCCC)N=C23)=CN=1
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