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CCT137690 efficiently inhibits histone H3 and TACC3 phosphorylation (Aurora B and Aurora A substrates
is an orally bioavailable inhibitor of monopolar spindle 1 (MPS1/TTK) kinase (IC50 = 1
InChi: InChI=1S/C12H26O8S/c1-15-3-4-16-5-6-17-7-8-18-9-10-19-11-12-20-21(2
VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily)
Phenamil methanesulfonate Catalog No.:M13338-10 CCT137690 efficiently inhibits histone H3Phenamil methanesulfonate, an analog of Amiloride (HY B0285), is a more potent and less reversible epithelial sodium channel (ENaC) blocker with an IC50 of 400 nM. Phenamil methanesulfonate is also a competive inhibitor of TRPP3 and inhibits TRPP3 mediated Ca2+ transport with an IC50 of 140 nM in a Ca2+ uptake assay. Phenamil methanesulfonate is an intriguing small molecule to promote bone repair by strongly activating BMP signaling pathway. Phenamil
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