A-192621 - CAS# 195529-54-5 0228 5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r

5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r

Hanrahan JW

5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4

cell cycle arrest and reduces colony formation

A-192621 - CAS# 195529-54-5 0228 5R)-2-(6-amino-9H-purin-9-yl)-5-((((1rA 192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4. 5 nM and a Ki of 8. 8 nM. The selectivity of A 192621 is 636 fold higher than ETA (IC50 of 4280 nM and Ki of 5600 nM). A 192621 promotes apoptosis in PASMCs. A 192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET 1 level. Product information CAS Number: 195529 54 5 Molecular Weight: 558. 66