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But if your foe happens to have an empty hand, they can choose to discard a card (even if they can't actually perform the action) and nullify the downside

If enough -1/-1 counters are put on a creature you control at the same time to make its toughness 0 or less, Buzzard-Wasp Colony's last ability will see all of the +1/+1 counters it had when it died as well as the -1/-1 counters it had, and an equal number of each of those types of counters (plus any other applicable counters) will be put onto Buzzard-Wasp Colony

New and Updated rules Incubate 701 : Transform this artifact." The back face is a colorless 0/0 Phyrexian artifact creature

It kills that Birds on turn one, it kills that Questing Beast on turn four