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19-pentamethyl-23
JH-II-127 D5904 19-pentamethyl-23JH II 127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6. 6 nM, 2. 2 nM ,47. 7 nM for LRRK2 wild type, LRRK2 G2019S, LRRK2 A2016T. IC50 value: 2. 2 n(LRRK2 G2019S), 6. 6 nM(LRRK2 wild type), 47. 7 nM (LRRK2 A2016T)Target: LRRK2JH II 127 is a potent and selective inhibitor of both wild type and G2019S mutant LRRK2. JH II 127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild type LRRK2 and G2019S
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